New Approaches to the Treatment of Vestibulovaginitis in Cows

Abstract

The objective of this study was to develop an effective treatment protocol for bovine vestibulovaginitis using a combination of broad-spectrum antibiotics, antiseptics, and immunostimulants. Clinical and vaginal examinations were performed to diagnose vestibulovaginitis in the study subjects. Based on the principle of analogues, two groups of seven cows each were formed. The control group received conventional therapy consisting of ethacridine lactate solution and syntomycin ointment. The experimental group was administered a combination of Cipromag 500 (ciprofloxacin), Miramistin, and Immunofan. Hematological and biochemical blood analyses, including leukocyte differential counts, were conducted prior to and throughout the treatment period. Additionally, the clinical progression of the disease was monitored daily. In the experimental group, normalization of hematological and biochemical blood parameters, as well as leukocyte profiles and overall clinical condition, was observed as early as days 2–3 of treatment and was fully achieved by day 6. In contrast, recovery in the control group was slower, with a delayed return to normal parameters.